Becn2^tm1.1Blev
Targeted Allele Detail

Summary

• Symbol: Becn2^tm1.1Blev
• Name: beclin 2; targeted mutation 1.1, Beth Levine
• MGI ID: MGI:5550535
• Gene: Becn2 Location: Chr1:175747895-175749791 bp, + strand Genetic Position: Chr1, Syntenic
• Alliance: Becn2^tm1.1Blev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203842
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 x C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced exons 1 and 2. Cre-mediated recombination removed the selection cassette. Western blot analysis confirmed the absence of protein expression in the brain. (J:203842)

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Becn2 Mutation: 0 strains or lines available

References

• Original: J:203842 He C, et al., Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. Cell. 2013 Aug 29;154(5):1085-99
• All: 4 reference(s)