Txndc2^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Txndc2^tm1.1Arte
• Name: thioredoxin domain containing 2 (spermatozoa); targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5550543
• Synonyms: Sptrx-1^-
• Gene: Txndc2 Location: Chr17:65944502-65949163 bp, - strand Genetic Position: Chr17, 34.99 cM, cytoband E1.2-E1.3
• Alliance: Txndc2^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205172
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site flanked the 5' end of exon 3 and an FRT-flanked Neo cassette and another loxP site flanked the 3' end of exon 3 (loxP-exon3-frt-neo-frt-loxP). Exon 3 and the neo cassette were removed following Cre recombinase activity. (J:205172)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Txndc2 Mutation: 26 strains or lines available

References

• Original: J:205172 Smith TB, et al., Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress. Free Radic Biol Med. 2013 Dec;65:872-81
• All: 1 reference(s)