Il6ra^tm1.2Jcbr
Targeted Allele Detail

Summary

• Symbol: Il6ra^tm1.2Jcbr
• Name: interleukin 6 receptor, alpha; targeted mutation 1.2, Jens C Bruning
• MGI ID: MGI:5550551
• Gene: Il6ra Location: Chr3:89776631-89820503 bp, - strand Genetic Position: Chr3, 39.19 cM
• Alliance: Il6ra^tm1.2Jcbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188445
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2, and an additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 and 3. Western blot analysis confirmed the absence of protein expression in the liver, spleen, thymus and lymph node. (J:188445)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il6ra Mutation: 35 strains or lines available

References

• Original: J:188445 Wunderlich CM, et al., Cutting edge: Inhibition of IL-6 trans-signaling protects from malaria-induced lethality in mice. J Immunol. 2012 May 1;188(9):4141-4
• All: 6 reference(s)