Glp1r^tm1.2Stof
Targeted Allele Detail

Summary

• Symbol: Glp1r^tm1.2Stof
• Name: glucagon-like peptide 1 receptor; targeted mutation 1.2, Doris Stoffers
• MGI ID: MGI:5551480
• Synonyms: Glp1r^CMVKO
• Gene: Glp1r Location: Chr17:31120841-31155484 bp, + strand Genetic Position: Chr17, 15.8 cM
• Alliance: Glp1r^tm1.2Stof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203834
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 6. An additional loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exon 6 and 7. (J:203834)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glp1r Mutation: 49 strains or lines available

References

• Original: J:203834 Clemmensen C, et al., Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice. Endocrinology. 2013 Nov;154(11):3978-83
• All: 3 reference(s)