Mfap5^tm1Mech
Targeted Allele Detail

Summary

• Symbol: Mfap5^tm1Mech
• Name: microfibrillar associated protein 5; targeted mutation 1, Robert P Mecham
• MGI ID: MGI:5551608
• Synonyms: Magp2^-
• Gene: Mfap5 Location: Chr6:122490543-122506249 bp, + strand Genetic Position: Chr6, 57.61 cM
• Alliance: Mfap5^tm1Mech page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203960
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin resistance cassette replaced exon 9, which encodes the matrix-binding domain. Western blot analysis confirmed the absence of protein expression in the lung. (J:203960)

Generation of the Mfap5^tm1Mech allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mfap5 Mutation: 16 strains or lines available

References

• Original: J:203960 Combs MD, et al., Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo. J Biol Chem. 2013 Oct 4;288(40):28869-80
• All: 4 reference(s)