Kdm6b^tm1.2Iwam
Targeted Allele Detail

Summary

• Symbol: Kdm6b^tm1.2Iwam
• Name: KDM1 lysine (K)-specific demethylase 6B; targeted mutation 1.2, Naoki Iwamori
• MGI ID: MGI:5551617
• Gene: Kdm6b Location: Chr11:69289334-69304501 bp, - strand Genetic Position: Chr11, 42.6 cM
• Alliance: Kdm6b^tm1.2Iwam page

Enlarged testes in Kdm6b^tm1.1Iwam/Kdm6b^tm1.2Iwam Tg(Stra8-icre)1Reb/0 males

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206350
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 14. An additional loxP site was inserted downstream of 21. Flp-mediated recombination removed the resistance cassette. Cre-mediated recombination removed exons 14 through 21. (J:206350)

Generation of the Kdm6b^tm1Iwam, Kdm6b^tm1.1Iwam, and Kdm6b^tm1.2Iwam alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm6b Mutation: 67 strains or lines available

References

• Original: J:206350 Iwamori N, et al., H3K27 demethylase, JMJD3, regulates fragmentation of spermatogonial cysts. PLoS One. 2013;8(8):e72689
• All: 1 reference(s)