Rhbdf1^tm1.1Mfm
Targeted Allele Detail

Summary

• Symbol: Rhbdf1^tm1.1Mfm
• Name: rhomboid 5 homolog 1; targeted mutation 1.1, Matthew Freeman
• MGI ID: MGI:5551620
• Synonyms: iRhom1^-
• Gene: Rhbdf1 Location: Chr11:32159585-32172300 bp, - strand Genetic Position: Chr11, 18.83 cM
• Alliance: Rhbdf1^tm1.1Mfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203951
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 18. Cre-mediated recombination removed exons 2 through 18 and left the resistance cassette intact. (J:203951)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rhbdf1 Mutation: 43 strains or lines available

References

• Original: J:203951 Christova Y, et al., Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation. EMBO Rep. 2013 Oct;14(10):884-90
• All: 2 reference(s)