Klf5^tm1.1Jtd
Targeted Allele Detail

Summary

• Symbol: Klf5^tm1.1Jtd
• Name: Kruppel-like transcription factor 5; targeted mutation 1.1, Jin-Tang Dong
• MGI ID: MGI:5551641
• Synonyms: Klf5^floxed
• Gene: Klf5 Location: Chr14:99536127-99550848 bp, + strand Genetic Position: Chr14, 49.43 cM, cytoband E2.1
• Alliance: Klf5^tm1.1Jtd page

Abnormal prostate morphology in Klf5^tm1.1Jtd/Klf5⁺ Tg(Pbsn-cre)4Prb/0 and Klf5^tm1.1Jtd/Klf5^tm1.1Jtd Tg(Pbsn-cre)4Prb/0 males

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206639
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exons 2 and 3 floxed. (J:206639)

Generation of the Klf5^tm1.1Jtd allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Klf5^tm1.1Jtd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf5 Mutation: 37 strains or lines available

References

• Original: J:206639 Xing C, et al., Different expression patterns and functions of acetylated and unacetylated Klf5 in the proliferation and differentiation of prostatic epithelial cells. PLoS One. 2013;8(6):e65538
• All: 2 reference(s)