Ttn^tm1.1Hgra
Targeted Allele Detail

Summary

• Symbol: Ttn^tm1.1Hgra
• Name: titin; targeted mutation 1.1, Henk Granzier
• MGI ID: MGI:5551762
• Synonyms: IG KO
• Gene: Ttn Location: Chr2:76534324-76812891 bp, - strand Genetic Position: Chr2, 45.13 cM, cytoband D
• Alliance: Ttn^tm1.1Hgra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206712
• Parent Cell Line: D1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced exons 30 through 38, which correspond to proximal Ig domains Ig3 through Ig11. Cre-mediated recombination removed the resistance cassette. (J:206712)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ttn Mutation: 1457 strains or lines available

References

• Original: J:206712 Chung CS, et al., Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction. Circulation. 2013 Jul 2;128(1):19-28
• All: 4 reference(s)