Mir205^tm1.2Yir
Targeted Allele Detail

Summary

• Symbol: Mir205^tm1.2Yir
• Name: microRNA 205; targeted mutation 1.2, Rui Yi
• MGI ID: MGI:5551770
• Gene: Mir205 Location: Chr1:193189771-193189838 bp, - strand Genetic Position: Chr1, 97.82 cM
• Alliance: Mir205^tm1.2Yir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201587
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the microRNA sequence. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted dowsntream of the microRNA sequence. Flp-mediated recombination removed the resistance cassette. Cre-mediated recombination removed the microRNA sequence. (J:201587)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir205 Mutation: 3 strains or lines available

References

• Original: J:201587 Wang D, et al., MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway. Nat Cell Biol. 2013 Oct;15(10):1153-63
• All: 1 reference(s)