Tg(Ly6a-cre/ERT2)1Isg
Transgene Detail

Summary

• Symbol: Tg(Ly6a-cre/ERT2)1Isg
• Name: transgene insertion 1, Isidro Sanchez-Garcia
• MGI ID: MGI:5551781
• Synonyms: Sca1-CreERT2
• Transgene: Tg(Ly6a-cre/ERT2)1Isg Location: unknown
• Alliance: Tg(Ly6a-cre/ERT2)1Isg page

Transgene origin

• Strain of Origin: CBA x C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Ly6a-cre/ERT2)1Isg expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Ly6a

• Mutation details: cDNA encoding a cre-ERT2 fusion was cloned into a vector containing Ly6a (specifically, a 14 kb Ly6E.1 genomic fragment). A 16 kb fragment was isolated, purified and used for microinjection. Founder/line information is not available. (J:206384)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ly6a (species not specified) Summary of all recombinase alleles driven by Ly6a.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:206384 Mainardi S, et al., Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):255-60
• All: 1 reference(s)