Wapl^tm1.2Jmpt
Targeted Allele Detail

Summary

• Symbol: Wapl^tm1.2Jmpt
• Name: WAPL cohesin release factor; targeted mutation 1.2, Jan-Michael Peters
• MGI ID: MGI:5551807
• Synonyms: Wapl^delta
• Gene: Wapl Location: Chr14:34395885-34469940 bp, + strand Genetic Position: Chr14, 20.84 cM
• Alliance: Wapl^tm1.2Jmpt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205429
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the resistance cassette. Cre-mediated recombination removed exons 3 and 4. (J:205429)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wapl Mutation: 169 strains or lines available

References

• Original: J:205429 Tedeschi A, et al., Wapl is an essential regulator of chromatin structure and chromosome segregation. Nature. 2013 Sep 26;501(7468):564-8
• All: 1 reference(s)