Myh9^tm1.1Dash
Targeted Allele Detail

Summary

• Symbol: Myh9^tm1.1Dash
• Name: myosin, heavy polypeptide 9, non-muscle; targeted mutation 1.1, Tadashi Matsushita
• MGI ID: MGI:5551833
• Synonyms: Myh9^R702C, R702C+
• Gene: Myh9 Location: Chr15:77644788-77726315 bp, - strand Genetic Position: Chr15, 36.81 cM
• Alliance: Myh9^tm1.1Dash page

Abnormal megakaryocytopoiesis in Myh9^tm1.1Dash/Myh9⁺ mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204923
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted Mutations: Insertion, Nucleotide substitutions Mutation details: Nucleotide susbtitutions in exon 16 result in the amino acid substitution of cysteine for arginine at position 702 (R702C). Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of exon 15. (J:204923)

Generation of the Myh9^tm1.1Dash allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myh9 Mutation: 219 strains or lines available

References

• Original: J:204923 Suzuki N, et al., Establishment of mouse model of MYH9 disorders: heterozygous R702C mutation provokes macrothrombocytopenia with leukocyte inclusion bodies, renal glomerulosclerosis and hearing disability. PLoS One. 2013;8(8):e71187
• All: 1 reference(s)