Cald1^tm1Chac
Targeted Allele Detail

Summary

• Symbol: Cald1^tm1Chac
• Name: caldesmon 1; targeted mutation 1, Samuel Chacko
• MGI ID: MGI:5552739
• Synonyms: CaD^-
• Gene: Cald1 Location: Chr6:34575433-34752404 bp, + strand Genetic Position: Chr6, 15.07 cM
• Alliance: Cald1^tm1Chac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202998
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 12 was replaced with one in which the ATPase inhibitory site was mutated (523Lys-524Val- 525Thr-526Ser-527Pro-528Thr-529Lys in exon 12 was changed to encode 523Gln-524Leu-525Thr-526Thr-527Cys-528Thr-529Ser). A neomycin resistance cassette and red fluorescent protein were inserted downstream of the modified exon 12. (J:202998)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cald1 Mutation: 38 strains or lines available

References

• Original: J:202998 Deng M, et al., Amino acid mutations in the caldesmon COOH-terminal functional domain increase force generation in bladder smooth muscle. Am J Physiol Renal Physiol. 2013 Nov;305(10):F1455-65
• All: 1 reference(s)