Pdpn^tm2.1Mlkn
Targeted Allele Detail

Summary

• Symbol: Pdpn^tm2.1Mlkn
• Name: podoplanin; targeted mutation 2.1, Mark L Kahn
• MGI ID: MGI:5552845
• Synonyms: Pdpn^f
• Gene: Pdpn Location: Chr4:142994001-143026134 bp, - strand Genetic Position: Chr4, 77.29 cM
• Alliance: Pdpn^tm2.1Mlkn page

VEGF-C-and galectin-8-induced lymphangiogenesis is diminished in Pdpn^tm2.1Mlkn/Pdpn^tm2.1Mlkn Tg(CAG-cre/Esr1*)5Amc/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205423
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted upstream of exon 2. (J:205423)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdpn Mutation: 29 strains or lines available

References

• Original: J:205423 Herzog BH, et al., Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013 Oct 3;502(7469):105-9
• All: 4 reference(s)