Clec1b^tm2Mlkn
Targeted Allele Detail

Summary

• Symbol: Clec1b^tm2Mlkn
• Name: C-type lectin domain family 1, member b; targeted mutation 2, Mark L Kahn
• MGI ID: MGI:5552846
• Synonyms: Clec-2^f
• Gene: Clec1b Location: Chr6:129374260-129382376 bp, + strand Genetic Position: Chr6, 63.3 cM, cytoband F3
• Alliance: Clec1b^tm2Mlkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205423
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3 and 4 were floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:205423)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec1b Mutation: 17 strains or lines available

References

• Original: J:205423 Herzog BH, et al., Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013 Oct 3;502(7469):105-9
• All: 6 reference(s)