Eif3m^tm1.1Nju
Targeted Allele Detail

Summary

• Symbol: Eif3m^tm1.1Nju
• Name: eukaryotic translation initiation factor 3, subunit M; targeted mutation 1.1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:5553070
• Gene: Eif3m Location: Chr2:104830001-104847372 bp, - strand Genetic Position: Chr2, 55.06 cM
• Alliance: Eif3m^tm1.1Nju page

Decreased fat pad size in Eif3m^tm1.1Nju/Eif3m⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204915
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 2. A neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exons 2 through 5 and the resistance cassette. (J:204915)

Generation of the Eif3m^tm1Nju and Eif3m^tm1.1Nju alleles

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eif3m Mutation: 19 strains or lines available

References

• Original: J:204915 Zeng L, et al., The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. J Biol Chem. 2013 Oct 18;288(42):30087-93
• All: 1 reference(s)