Ccdc7a^{Tg(Prnp-Sirt1)10Imai}
Transgenic Allele Detail

Summary

• Symbol: Ccdc7a^{Tg(Prnp-Sirt1)10Imai}
• Name: coiled-coil domain containing 7A; transgene insertion 10, Shin-ichiro Imai
• MGI ID: MGI:5553098
• Synonyms: BRASTO
• Gene: Ccdc7a Location: Chr8:129460715-129791973 bp, - strand Genetic Position: Chr8, 76.12 cM, cytoband E2
• Alliance: Ccdc7a^{Tg(Prnp-Sirt1)10Imai} page

Transgene origin

• Strain of Origin: C57BL/6J x CBA

Transgene description

• Transgene Type: Transgenic (Hypomorph, Inserted expressed sequence)
• Mutation: Insertion
• Ccdc7a^{Tg(Prnp-Sirt1)10Imai} expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sirt1 (MGI:2135607)

• Mutation details: The mouse promoter drives brain-specific expression of an HA-tagged 2.3 kb fragment of the mouse cDNA. Lines 1 (2.5- to 5.1-fold increased expression) and 10 (1.5- to 2.5-fold increased expression) were generated. Line 10 contains 14 copies of the transgene inserted into a long intron. Transcript expression of splice variant B is decreased in the testis. (J:162852, J:203814)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccdc7a Mutation: 54 strains or lines available

References

• Original: J:162852 Satoh A, et al., SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. J Neurosci. 2010 Jul 28;30(30):10220-32
• All: 3 reference(s)