Igh^tm1.1Vmd
Targeted Allele Detail

Summary

• Symbol: Igh^tm1.1Vmd
• Name: immunoglobulin heavy chain complex; targeted mutation 1.1, Vishva M Dixit
• MGI ID: MGI:5553164
• Synonyms: SmuKI
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201147
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted Mutations: Insertion, Intragenic deletion Mutation details: The Switch epsilon region (the weakest switch region) was replaced with a floxed neomycin resistance cassette and the Switch mu region (the strongest switch region). Cre-mediated recombination removed the resistance cassette. (J:201147)

Generation of the Igh^tm1.1Vmd allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 44 strains or lines available

References

• Original: J:201147 Misaghi S, et al., Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15770-5
• All: 1 reference(s)