Lrig2^tm1.1Hhed
Targeted Allele Detail

Summary

• Symbol: Lrig2^tm1.1Hhed
• Name: leucine-rich repeats and immunoglobulin-like domains 2; targeted mutation 1.1, Hakan Hedman
• MGI ID: MGI:5553453
• Synonyms: Lrig2E12^-
• Gene: Lrig2 Location: Chr3:104361296-104419251 bp, - strand Genetic Position: Chr3, 45.62 cM
• Alliance: Lrig2^tm1.1Hhed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205929
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 12. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 12. Cre-mediated recombination removed exon 12 and the resistance cassette. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:205929)

Generation of the Lrig2^tm1.1Hhed allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrig2 Mutation: 75 strains or lines available

References

• Original: J:205929 Rondahl V, et al., Lrig2-deficient mice are protected against PDGFB-induced glioma. PLoS One. 2013;8(9):e73635
• All: 2 reference(s)