Clp1^tm1.1Pngr
Targeted Allele Detail

Summary

• Symbol: Clp1^tm1.1Pngr
• Name: CLP1, cleavage and polyadenylation factor I subunit; targeted mutation 1.1, Josef M Penninger
• MGI ID: MGI:5554792
• Synonyms: Clp1^K, Clp1^K127A
• Gene: Clp1 Location: Chr2:84553466-84557631 bp, - strand Genetic Position: Chr2, 49.45 cM
• Alliance: Clp1^tm1.1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196364
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A loxP site was inserted upstream of a modified exon 2 in which nucleotide substitutions (AAG to GCG) results in the amino acid substitution of alanine for lysine at position 127 (K127A). Flp-mediated recombination removed the FRT- and loxP-flanked neomycin resistance cassette inserted downstream of the modified exon 2. The product of this allele is predicted to be a kinase dead form. (J:196364)

Disease models

Expression

In Mice Carrying this Mutation:	4 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clp1 Mutation: 22 strains or lines available

References

• Original: J:196364 Hanada T, et al., CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 2013 Mar 28;495(7442):474-80
• All: 3 reference(s)