Camk2d^tm1.1Mean
Targeted Allele Detail

Summary

• Symbol: Camk2d^tm1.1Mean
• Name: calcium/calmodulin-dependent protein kinase II, delta; targeted mutation 1.1, Mark Anderson
• MGI ID: MGI:5555902
• Synonyms: CaMKIIdelta M281,282V, MM-VV
• Gene: Camk2d Location: Chr3:126389951-126639975 bp, + strand Genetic Position: Chr3, 55.97 cM
• Alliance: Camk2d^tm1.1Mean page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207291
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 11 was replaced with a modified exon 11 in which nucleotide substitutions result in the amino acid substitution of valine for methionine at positions 281 and 282. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of exon 12. The product of this allele is predicted to be oxidant-resistant. (J:207291)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camk2d Mutation: 44 strains or lines available

References

• Original: J:207291 Luo M, et al., Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. J Clin Invest. 2013 Mar 1;123(3):1262-74
• All: 10 reference(s)