Tg(CAG-LARGE)126Fmu
Transgene Detail

Summary

• Symbol: Tg(CAG-LARGE)126Fmu
• Name: transgene insertion 126, Francesco Muntoni
• MGI ID: MGI:5556056
• Transgene: Tg(CAG-LARGE)126Fmu Location: unknown
• Alliance: Tg(CAG-LARGE)126Fmu page

Transgene origin

• Strain of Origin: C57BL/10 x CBA/Ca

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-LARGE)126Fmu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LARGE1 (9215)

  Large1

  (MGI:1342270)

• Mutation details: This transgene consists of a human cytomegalovirus enhancer, chicken beta-actin promoter, human LARGE fused with the V5 epitope at the C terminal end, and a rabbit beta-globin 3' flanking sequence including a polyadenylation signal. Four lines were established: 68, 76, 116, and 126. (J:168339)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:168339 Brockington M, et al., Transgenic overexpression of LARGE induces alpha-dystroglycan hyperglycosylation in skeletal and cardiac muscle. PLoS One. 2010;5(12):e14434
• All: 3 reference(s)