Sirt3^tm1.1Auw
Targeted Allele Detail

Summary

• Symbol: Sirt3^tm1.1Auw
• Name: sirtuin 3; targeted mutation 1.1, Johan Auwerx
• MGI ID: MGI:5556075
• Synonyms: Sirt3^L2
• Gene: Sirt3 Location: Chr7:140443579-140462222 bp, - strand Genetic Position: Chr7, 86.07 cM, cytoband F4
• Alliance: Sirt3^tm1.1Auw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207274
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert loxP sites flanking exons 2-3 of the gene, and a FRT-flanked neomycin selection cassette was inserted upstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:207274)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sirt3 Mutation: 32 strains or lines available

References

• Original: J:207274 Fernandez-Marcos PJ, et al., Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis. Sci Rep. 2012;2:425
• All: 12 reference(s)