Gt(ROSA)26Sortm1(Notch3*)Sfr
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm1(Notch3*)Sfr |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Silvia Fre |
MGI ID: |
MGI:5556106 |
Synonyms: |
R26-N3ICSAT |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm1(Notch3*)Sfr page
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Germline Transmission: |
Earliest citation of germline transmission:
J:201985
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6NTac
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Allele Type: |
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Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm1(Notch3*)Sfr expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
mouse |
Notch3 (MGI:99460) |
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Mutation details: A floxed stop cassette followed by a cDNA fragment encoding the mouse Notch3 intracellular domain (amino acids 1668 to 2318), IRES and sequence for YFP were inserted into intron 1. The Notch3 fragment acts as a constitutively active receptor.
(J:201985)
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Schematic of the Gt(ROSA)26Sortm1(Notch3*)Sfr allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
992 strains or lines available
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Original: |
J:201985 Lafkas D, et al., Notch3 marks clonogenic mammary luminal progenitor cells in vivo. J Cell Biol. 2013 Oct 14;203(1):47-56 |
All: |
2 reference(s) |
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