Mastl^tm1.2Mama
Targeted Allele Detail

Summary

• Symbol: Mastl^tm1.2Mama
• Name: microtubule associated serine/threonine kinase-like; targeted mutation 1.2, Marcos Malumbres
• MGI ID: MGI:5556127
• Synonyms: Mastl(-)
• Gene: Mastl Location: Chr2:23006549-23046036 bp, - strand Genetic Position: Chr2, 15.23 cM
• Alliance: Mastl^tm1.2Mama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201971
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted in intron 3 and an FRT flanked neo cassette and loxP site were inserted in intron 4 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exon 4. (J:201971)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mastl Mutation: 36 strains or lines available

References

• Original: J:201971 Alvarez-Fernandez M, et al., Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17374-9
• All: 1 reference(s)