Dzip1^tm1.1Blnw
Targeted Allele Detail

Summary

• Symbol: Dzip1^tm1.1Blnw
• Name: DAZ interacting protein 1; targeted mutation 1.1, Baolin Wang
• MGI ID: MGI:5557987
• Synonyms: Dzip1^deltaE1-2
• Gene: Dzip1 Location: Chr14:119112932-119162872 bp, - strand Genetic Position: Chr14, 62.56 cM, cytoband E4
• Alliance: Dzip1^tm1.1Blnw page

The neural tube and somites are underdeveloped in Dzip1^tm1.1Blnw/Dzip1^tm1.1Blnw embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207249
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Intragenic deletion Mutation details: Exons 2 and 3 were replaced with a floxed neomycin resistance cassette. Cre-mediated recombination removed the selection cassette. Western blot analysis confirmed the expression of a truncated protein in embryos. (J:207249)

Generation of the Dzip1^tm1.1Blnw allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dzip1 Mutation: 38 strains or lines available

References

• Original: J:207249 Wang C, et al., Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. J Biol Chem. 2013 Oct 11;288(41):29518-29
• All: 1 reference(s)