Sirpa^tm1Umri
Targeted Allele Detail

Summary

• Symbol: Sirpa^tm1Umri
• Name: signal-regulatory protein alpha; targeted mutation 1, Hisashi Umemori
• MGI ID: MGI:5558020
• Gene: Sirpa Location: Chr2:129434755-129474148 bp, + strand Genetic Position: Chr2, 63.19 cM, cytoband F3
• Alliance: Sirpa^tm1Umri page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204011
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 71 nucleotides in exon 1, including the translation start site, were replaced with a floxed full-length mouse cDNA of the gene, an EGFP gene and an FRT-flanked neomycin resistance cassette. (J:204011)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirpa Mutation: 51 strains or lines available

References

• Original: J:204011 Toth AB, et al., Synapse maturation by activity-dependent ectodomain shedding of SIRPalpha. Nat Neurosci. 2013 Oct;16(10):1417-25
• All: 4 reference(s)