Htra1^tm1.1Pfi
Targeted Allele Detail

Summary

• Symbol: Htra1^tm1.1Pfi
• Name: HtrA serine peptidase 1; targeted mutation 1.1, Pfizer, Ltd
• MGI ID: MGI:5558036
• Gene: Htra1 Location: Chr7:130537933-130587388 bp, + strand Genetic Position: Chr7, 73.2 cM
• Alliance: Htra1^tm1.1Pfi page

Increase in bone volume in Htra1^tm1.1Pfi/Htra1^tm1.1Pfi mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206395
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 2. A neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette and exons 2 and 3. (J:206395)

Generation of the Htra1^tm1.1Pfi allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htra1 Mutation: 54 strains or lines available

References

• Original: J:206395 Graham JR, et al., Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation. PLoS One. 2013;8(9):e74094
• All: 1 reference(s)