Dlg1^tm1.1Rlh
Targeted Allele Detail

Summary

• Symbol: Dlg1^tm1.1Rlh
• Name: discs large MAGUK scaffold protein 1; targeted mutation 1.1, Richard L Huganir
• MGI ID: MGI:5558041
• Gene: Dlg1 Location: Chr16:31482261-31692174 bp, + strand Genetic Position: Chr16, 22.4 cM
• Alliance: Dlg1^tm1.1Rlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202688
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the exon encoding the carboxy terminus of the first PDZ domain and the amino terminus of the second PZD domain and an FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of this exon. Flp-mediated recombination was used to remove the selection cassette. Cre-mediated recombination removed the exon. (J:202688)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlg1 Mutation: 76 strains or lines available

References

• Original: J:202688 Noseda R, et al., DDIT4/REDD1/RTP801 is a novel negative regulator of Schwann cell myelination. J Neurosci. 2013 Sep 18;33(38):15295-305
• All: 1 reference(s)