Ifngr1^tm1.2Rds
Targeted Allele Detail

Summary

• Symbol: Ifngr1^tm1.2Rds
• Name: interferon gamma receptor 1; targeted mutation 1.2, Robert D Schreiber
• MGI ID: MGI:5558049
• Synonyms: Ifngr1WU^-
• Gene: Ifngr1 Location: Chr10:19467697-19485977 bp, + strand Genetic Position: Chr10, 8.49 cM
• Alliance: Ifngr1^tm1.2Rds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206257
• Parent Cell Line: B6/BLU (ES Cell)
• Strain of Origin: C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 4. Cre-mediated recombination removed the selection cassette and exons 3 and 4. Flow cytometry confirmed the absence of protein expression in spleen, peripheral blood leukocytes and thymus. (J:206257)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ifngr1 Mutation: 53 strains or lines available

References

• Original: J:206257 Lee SH, et al., Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFN-gamma receptor subunit 1 (IFNGR1). J Immunol. 2013 Oct 15;191(8):4223-34
• All: 4 reference(s)