Kiss1r^tm1.1Aeh
Targeted Allele Detail

Summary

• Symbol: Kiss1r^tm1.1Aeh
• Name: KISS1 receptor; targeted mutation 1.1, Allan E Herbison
• MGI ID: MGI:5558092
• Synonyms: Gpr54^f, Gpr54^loxP
• Gene: Kiss1r Location: Chr10:79752805-79758107 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Kiss1r^tm1.1Aeh page

Reduced gonadal size in Kiss1r^tm1.1Aeh/Kiss1r^tm1.1Aeh Tg(Gnrh1-cre)1Dlc mice is rescued by the Tg(Gnrh1-Kiss1r)#Aeh transgene

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206044
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:206044)

Generation of the Kiss1r^tm1.1Aeh allele

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kiss1r Mutation: 21 strains or lines available

References

• Original: J:206044 Kirilov M, et al., Dependence of fertility on kisspeptin-Gpr54 signaling at the GnRH neuron. Nat Commun. 2013;4:2492
• All: 5 reference(s)