Wdpcp^cys40
Chemically induced Allele Detail

Summary

• Symbol: Wdpcp^cys40
• Name: WD repeat containing planar cell polarity effector; cys40
• MGI ID: MGI:5558098
• Synonyms: Cys40, Wdpcp^m
• Gene: Wdpcp Location: Chr11:21521969-21848686 bp, + strand Genetic Position: Chr11, 13.9 cM
• Alliance: Wdpcp^cys40 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: An A to G substitution was detected at nucleotide 224 of the mRNA, corresponding to the 8th base before the splice donor site of exon 5, resulting in a premature stop codon (S54X) after amino acid 54. Homozygous MEFs showed loss of protein immunostaining indicating this is a null allele. (J:94456, J:205269)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdpcp Mutation: 33 strains or lines available

References

• Original: J:205269 Cui C, et al., Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 2013 Nov;11(11):e1001720
• All: 4 reference(s)