Wdpcp^tm1.1Clo
Targeted Allele Detail

Summary

• Symbol: Wdpcp^tm1.1Clo
• Name: WD repeat containing planar cell polarity effector; targeted mutation 1.1, Cecilia W Lo
• MGI ID: MGI:5558100
• Gene: Wdpcp Location: Chr11:21521969-21848686 bp, + strand Genetic Position: Chr11, 13.9 cM
• Alliance: Wdpcp^tm1.1Clo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205269
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 5 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 5 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exon 5. (J:205269)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdpcp Mutation: 33 strains or lines available

References

• Original: J:205269 Cui C, et al., Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 2013 Nov;11(11):e1001720
• All: 2 reference(s)