Mavs^tm1Tsse
Targeted Allele Detail

Summary

• Symbol: Mavs^tm1Tsse
• Name: mitochondrial antiviral signaling protein; targeted mutation 1, Tsukasa Seya
• MGI ID: MGI:5558893
• Gene: Mavs Location: Chr2:131075983-131089945 bp, + strand Genetic Position: Chr2, 63.3 cM
• Alliance: Mavs^tm1Tsse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179625
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 2 and 3. RT-PCR confirmed the absence of transcript expression. (J:179625)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mavs Mutation: 36 strains or lines available

References

• Original: J:179625 Oshiumi H, et al., The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection. J Immunol. 2011 Nov 15;187(10):5320-7
• All: 11 reference(s)