Megf8^tm1.2Ddg
Targeted Allele Detail

Summary

• Symbol: Megf8^tm1.2Ddg
• Name: multiple EGF-like-domains 8; targeted mutation 1.2, David D Ginty
• MGI ID: MGI:5558931
• Synonyms: Megf8^Flox
• Gene: Megf8 Location: Chr7:25016589-25065342 bp, + strand Genetic Position: Chr7, 13.75 cM
• Alliance: Megf8^tm1.2Ddg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206541
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The final exon was flanked by a loxP site and an FRT-flanked neomycin resistance cassette with a 3' loxP site. Flp-mediated recombination removed the selection cassette and left the last exon floxed. (J:206541)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Megf8 Mutation: 97 strains or lines available

References

• Original: J:206541 Engelhard C, et al., MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons. Elife. 2013;2:e01160
• All: 1 reference(s)