Grm3^tm1Vbn
Targeted Allele Detail

Summary

• Symbol: Grm3^tm1Vbn
• Name: glutamate receptor, metabotropic 3; targeted mutation 1, Valeria Bruno
• MGI ID: MGI:5558949
• Gene: Grm3 Location: Chr5:9535541-9775170 bp, - strand Genetic Position: Chr5, 3.69 cM
• Alliance: Grm3^tm1Vbn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123686
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene and neomycin resistance cassette was inserted between exon 2 and 3. In situ hybridization confirmed the absence of transcript expression in the brain. (J:123686)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm3 Mutation: 54 strains or lines available

References

• Original: J:123686 Corti C, et al., The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection. J Neurosci. 2007 Aug 1;27(31):8297-308
• All: 5 reference(s)