Memo1^tm1.1Neh
Targeted Allele Detail

Summary

• Symbol: Memo1^tm1.1Neh
• Name: mediator of cell motility 1; targeted mutation 1.1, Nancy E Hynes
• MGI ID: MGI:5559022
• Synonyms: Memo^fl
• Gene: Memo1 Location: Chr17:74506031-74602516 bp, - strand Genetic Position: Chr17, 45.63 cM, cytoband E2
• Alliance: Memo1^tm1.1Neh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206626
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:206626)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Memo1 Mutation: 47 strains or lines available

References

• Original: J:206626 Haenzi B, et al., Loss of Memo, a novel FGFR regulator, results in reduced lifespan. FASEB J. 2014 Jan;28(1):327-36
• All: 5 reference(s)