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Tg(Myh6-Gnaq*Q209L)52Ejne
Transgene Detail
Summary
Symbol: Tg(Myh6-Gnaq*Q209L)52Ejne
Name: transgene insertion 52, E J Neer
MGI ID: MGI:5559165
Synonyms: alphaQ*52
Transgene: Tg(Myh6-Gnaq*Q209L)52Ejne  Location: unknown  
Alliance: Tg(Myh6-Gnaq*Q209L)52Ejne page
Gross and microscopic pathology of hearts from Tg(Myh6-Gnaq*Q209L)52Ejne/? mice

Show the 1 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Gnaq*Q209L)52Ejne expresses 1 gene
 
Mutation detailsThe murine 5.5-kb alpha-myosin heavy chain promoter drives the cardiac-specific expression of mouse hemagglutinin (HA) epitope-tagged constitutively active (Q209L mutation) G protein alpha q subunit. Two lines, 44 and 52, were made. (J:204274)
Schematic representation of the transgenic vector for Tg(Myh6-Gnaq*Q209L)52Ejne
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:204274 Mende U, et al., Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13893-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory