Tg(Myh6-Gnaq*Q209L)52Ejne
Transgene Detail
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Symbol: |
Tg(Myh6-Gnaq*Q209L)52Ejne |
Name: |
transgene insertion 52, E J Neer |
MGI ID: |
MGI:5559165 |
Synonyms: |
alphaQ*52 |
Transgene: |
Tg(Myh6-Gnaq*Q209L)52Ejne Location: unknown
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Alliance: |
Tg(Myh6-Gnaq*Q209L)52Ejne page
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Gross and microscopic pathology of hearts from Tg(Myh6-Gnaq*Q209L)52Ejne/? mice
Show the 1 phenotype image(s) involving this allele.
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Constitutively active, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Myh6-Gnaq*Q209L)52Ejne expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Gnaq (MGI:95776) |
this mutation renders Gnaq constitutively active |
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Mutation details: The murine 5.5-kb alpha-myosin heavy chain promoter drives the cardiac-specific expression of mouse hemagglutinin (HA) epitope-tagged constitutively active (Q209L mutation) G protein alpha q subunit. Two lines, 44 and 52, were made.
(J:204274)
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Schematic representation of the transgenic vector for Tg(Myh6-Gnaq*Q209L)52Ejne |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:204274 Mende U, et al., Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13893-8 |
All: |
3 reference(s) |
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