Gt(ROSA)26Sor^{tm1.1(Mir26a-1)Coh}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(Mir26a-1)Coh}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, City of Hope, Beckman Research Institute
• MGI ID: MGI:5559204
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(Mir26a-1)Coh} page

Increase in the number of islets in Gt(ROSA)26Sor^{tm1.1(Mir26a-1)Coh}/? pancreas

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201964
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(Mir26a-1)Coh} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mir26a-1 (MGI:2676900)

• Mutation details: A construct containing a CAG promoter floxed neo-stop cassette, a Mir26a-1 genomic DNA, an FRT flanked IRES-GFP cassette, and poly A sequence, was inserted in intron 1 via homologous recombination. Cre mediated recombination removed the floxed neo-stop cassette. (J:201964)

Generation of the Gt(ROSA)26Sor^{tm1.1(Mir26a-1)Coh} allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:201964 Fu X, et al., MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17892-7
• All: 3 reference(s)