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Fxr1tm1Drad
Targeted Allele Detail
Summary
Symbol: Fxr1tm1Drad
Name: FMR1 autosomal homolog 1; targeted mutation 1, Danuta Radzioch
MGI ID: MGI:5559216
Gene: Fxr1  Location: Chr3:34074133-34124129 bp, + strand  Genetic Position: Chr3, 16.41 cM, cytoband B
Alliance: Fxr1tm1Drad page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96927
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into the gene. Western blot analysis confirmed the absence of protein in immortalized macrophage cell lines derived from bone marrow. (J:96927)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fxr1 Mutation:  166 strains or lines available
References
Original:  J:96927 Garnon J, et al., Fragile X-related protein FXR1P regulates proinflammatory cytokine tumor necrosis factor expression at the post-transcriptional level. J Biol Chem. 2005 Feb 18;280(7):5750-63
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory