Fxr1^tm1Drad
Targeted Allele Detail

Summary

• Symbol: Fxr1^tm1Drad
• Name: FMR1 autosomal homolog 1; targeted mutation 1, Danuta Radzioch
• MGI ID: MGI:5559216
• Gene: Fxr1 Location: Chr3:34074133-34124129 bp, + strand Genetic Position: Chr3, 16.41 cM, cytoband B
• Alliance: Fxr1^tm1Drad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96927
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into the gene. Western blot analysis confirmed the absence of protein in immortalized macrophage cell lines derived from bone marrow. (J:96927)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fxr1 Mutation: 164 strains or lines available

References

• Original: J:96927 Garnon J, et al., Fragile X-related protein FXR1P regulates proinflammatory cytokine tumor necrosis factor expression at the post-transcriptional level. J Biol Chem. 2005 Feb 18;280(7):5750-63
• All: 2 reference(s)