Ppp1r12a^tm1Mzhu
Targeted Allele Detail

Summary

• Symbol: Ppp1r12a^tm1Mzhu
• Name: protein phosphatase 1, regulatory subunit 12A; targeted mutation 1, Min-Sheng Zhu
• MGI ID: MGI:5559675
• Gene: Ppp1r12a Location: Chr10:107997913-108115846 bp, + strand Genetic Position: Chr10, 56.33 cM, cytoband C
• Alliance: Ppp1r12a^tm1Mzhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207752
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 1. (J:207752)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r12a Mutation: 62 strains or lines available

References

• Original: J:207752 He WQ, et al., Altered contractile phenotypes of intestinal smooth muscle in mice deficient in myosin phosphatase target subunit 1. Gastroenterology. 2013 Jun;144(7):1456-65, 1465.e1-5
• All: 8 reference(s)