Stk25^tm1.2Bwh
Targeted Allele Detail

Summary

• Symbol: Stk25^tm1.2Bwh
• Name: serine/threonine kinase 25 (yeast); targeted mutation 1.2, Brian Howell
• MGI ID: MGI:5559696
• Synonyms: Stk25^-
• Gene: Stk25 Location: Chr1:93548473-93581937 bp, - strand Genetic Position: Chr1, 47.25 cM
• Alliance: Stk25^tm1.2Bwh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203414
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination inserted a loxP site before exon 4, a FRT-flanked neo cassette in intron 5 and followed by another loxP sequence. Cre-mediated recombination removed exons 4 and 5, resulting a frameshift and termination in exon 6. Western blot analysis confirms the absence of protein expression in brain lysates from homozygous mice. (J:203414)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk25 Mutation: 24 strains or lines available

References

• Original: J:203414 Matsuki T, et al., Acute inactivation of the serine-threonine kinase Stk25 disrupts neuronal migration. Neural Dev. 2013 Nov 13;8(1):21
• All: 8 reference(s)