Tg(Myh6-PRKCE*A159E)388Robo
Transgene Detail

Summary

• Symbol: Tg(Myh6-PRKCE*A159E)388Robo
• Name: transgene insertion 388, Roberto Bolli
• MGI ID: MGI:5559989
• Transgene: Tg(Myh6-PRKCE*A159E)388Robo Location: unknown
• Alliance: Tg(Myh6-PRKCE*A159E)388Robo page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Full-length rabbit PRKCE with the A to E substitution at amino acid 159 is under the control of the mouse alpha-myosin heavy chain promoter. This mutation prevents the pseudosubstrate domain from binding to the catalytic domain and renders it constitutively active. Northern blot analysis indicates 15-fold increase in PRKCE mRNA level and immunoblot analysis shows 9-fold increase in protein. (J:133484)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:133484 Takeishi Y, et al., Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy. Circ Res. 2000 Jun 23;86(12):1218-23
• All: 1 reference(s)