Tg(tetO-Mirlet7a/Mir155,Vil1-rtTA)#Aru
Transgene Detail

Summary

• Symbol: Tg(tetO-Mirlet7a/Mir155,Vil1-rtTA)#Aru
• Name: transgene insertion, Anil K Rustgi
• MGI ID: MGI:5560198
• Synonyms: iiLet7
• Transgene: Tg(tetO-Mirlet7a/Mir155,Vil1-rtTA)#Aru Location: unknown
• Alliance: Tg(tetO-Mirlet7a/Mir155,Vil1-rtTA)#Aru page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Transactivator)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The construct consists of the TRE3G (a third-generation tet-responsive promoter), and EmGFP region, a fusion of Mirlet7a to a modified mir155 terminal loop, an SV40 polyadenylation signal, a 13 kb mouse Vil1 promoter, and a rtTA-M2 sequence. The Mirlet7a/mir155 fusion shRNA is not recognized by LIN28A or LIN28B. (J:202923)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:202923 Madison BB, et al., LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. Genes Dev. 2013 Oct 15;27(20):2233-45
• All: 2 reference(s)