Mirc31^tm1.1Aru
Targeted Allele Detail

Summary

• Symbol: Mirc31^tm1.1Aru
• Name: microRNA cluster 31, including Mirlet7c-2 through Mirlet7b; targeted mutation 1.1, Anil K Rustgi
• MGI ID: MGI:5560203
• Gene: Mirc31 Location: Chr15:85590804-85591604 bp Genetic Position: Chr15, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202923
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the microRNA stem loop and an FRT flanked neo cassette and a loxP site were inserted downstream of the microRNA stem loop. Flp mediated recombination removed the neo cassette. (J:202923)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc31 Mutation: 2 strains or lines available

References

• Original: J:202923 Madison BB, et al., LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. Genes Dev. 2013 Oct 15;27(20):2233-45
• All: 3 reference(s)