Habp2^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Habp2^tm1Lex
• Name: hyaluronic acid binding protein 2; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5560205
• Gene: Habp2 Location: Chr19:56275569-56309254 bp, + strand Genetic Position: Chr19, 51.79 cM
• Alliance: Habp2^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207454
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A promoter-less lacZ and neomycin resistance cassette replaced 65 bp of exon 1. Western blot analysis confirmed the absence of protein expression in the plasma. (J:207454)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Habp2 Mutation: 29 strains or lines available

Notes

ES cell = 2E9 (129S/SvEvBrd)

References

• Original: J:207454 Borkham-Kamphorst E, et al., Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men. J Hepatol. 2013 Jan;58(1):104-11
• All: 3 reference(s)