b2b2101Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b2101Clo
• Name: Mutant line 2101; Bench to Bassinet Program (B2B/CVDC), mutation 2101 Cecilia Lo
• MGI ID: MGI:5560802
• Gene: b2b2101Clo Location: unknown
• Alliance: b2b2101Clo page

Mutant 2101-005-1 (E15.5) has an interrupted aorta with a RAA and parallel outflow tracts which is diagnosed as DORV by EFIC imaging

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. (J:175213)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b2101Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis:
Cardiovascular Phenotype (one mutant): Double outlet right ventricle (DORV) with subaortic ventricular septal defect (VSD), right aortic arch (RAA), interrupted aortic arch (IAA), vascular ring, right atrial isomerism, and dual inferior vena cava (IVC)
Noncardiovascular Phenotype (one mutant): Microphthalmia

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0600	Double outlet right ventricle
1250	Interrupted aortic arch
1300	Ventricular septal defect
2700	Abnormal aortic arch
2720	Right aortic arch
2760	Vascular ring
2810	Inferior vena cava anomaly
4877	Microphthalmia
4906	Non-cardiac abnormality

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)