Mpst^tm1.1Nori
Targeted Allele Detail

Summary

• Symbol: Mpst^tm1.1Nori
• Name: mercaptopyruvate sulfurtransferase; targeted mutation 1.1, Noriyuki Nagahara
• MGI ID: MGI:5560820
• Gene: Mpst Location: Chr15:78290918-78298213 bp, + strand Genetic Position: Chr15, 37.47 cM, cytoband E2
• Alliance: Mpst^tm1.1Nori page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207803
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted into exon 2. Cre-mediated recombination removed exon 1, part of exon 2 and the selection cassette. Western blot analysis confirmed the absence of protein expression in the kidney, lung, liver and brain. (J:207803)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mpst Mutation: 23 strains or lines available

References

• Original: J:207803 Nagahara N, et al., Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria. Sci Rep. 2013;3:1986
• All: 5 reference(s)