Lrp4^tm3Her
Targeted Allele Detail

Summary

• Symbol: Lrp4^tm3Her
• Name: low density lipoprotein receptor-related protein 4; targeted mutation 3, Joachim Herz
• MGI ID: MGI:5561037
• Synonyms: Lrp4^deltaICD
• Gene: Lrp4 Location: Chr2:91287856-91344124 bp, + strand Genetic Position: Chr2, 50.63 cM
• Alliance: Lrp4^tm3Her page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207796
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A Myc-tagged sequence encoding the transmembrane domain, bovine growth hormone 3' UTR and neomycin resistance cassette replaced the endogenous sequence for the transmembrane domain. The resulting product lacks the intracellular domain (which is normally downstream of the transmembrane domain). (J:207796)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp4 Mutation: 98 strains or lines available

References

• Original: J:207796 Choi HY, et al., APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice. Elife. 2013;2:e00220
• All: 1 reference(s)